黄勇

　　一、个人基本信息

　　黄勇，男，1975年出生，山西省忻州人，现为365.com教授、博士生导师，中国畜牧兽医学会兽医病理学分会理事，陕西省实验动物学会理事，中国微生物学会终生会员，中国免疫学会高级会员，中国生物化学与分子生物学会会员。

　　二、教育及研究经历

　　1994 年—1999年 天津医科大学临床医学专业获 医学学士 学位2001 年—2004年 第四军医大学生物化学与分子生物学专业获 医学硕士 学位 2004 年—2007年 第四军医大学生物化学与分子生物学专业获 医学博士 学位 2008年—2011年 美国国家食品药物管理局生物制品评价研究中心分子病毒学实验室从事博士后研究工作。

　　三、研究方向及开设课程

　　研究方向：感染性疾病的免疫病理机制、新型疫苗与诊断新技术研发

　　开设课程：动物病理解剖学、细胞与分子病理学

　　四、代表性学术成果

　　BeiBei Cui, Wenli Liu, Xiaoya Wang, Yu Chen, Qian Du, Xiaomin Zhao, Hai Zhang, Shan-lu Liu, Dewen Tong*, Yong Huang*. Brucella Omp25 Upregulates miR-155, miR-21-5p, and miR-23b to Inhibit Interleukin-12 Production via Modulation of Programmed Death-1 Signaling in Human Monocyte/ Macrophages. Front Immunol. 2017,  eCollection 2017, 8: 708. (SCI, IF: 6.429).

　　Xiaomao Luo, Xiujuan Zhang, Xingchen Wu, Xuefeng Yang, Cong Han, Zhenyu Wang, Qian Du, Xiaomin Zhao, Shan-Lu Liu, Dewen Tong*, Yong Huang*. Brucella down-regulates TNF-α to promote intracellular survival via Omp25 regulation. Frontiers in immunology,2018, DOI: 10.3389/fimmu.2017.02013. (SCI, IF: 6.429).

　　Tongtong Wang, Qian Du, Xingchen Wu, Yingying Niu, Lijuan Guan, Zhenyu Wang, Xiaomin Zhao, Shan-Lu Liu, Dewen Tong*, Yong Huang*, Porcine MKRN1 modulates the replication and pathogenesis of PCV2 by inducing capsid protein ubiquitination and degradation. Journal of Virology. 2018 March 2. Accept. (SCI, IF: 4.663).

　　Xiaomin Zhao, Xiaoyuan Bai, Lijuan Guan, Juejun Li, Xiangjun Song, Xuelian Ma, Jianxiong Guo, Zhichao Zhang, Qian Du, Yong Huang*, Dewen Tong*, microRNA-4331 promotes TGEV-induced mitochondrial damage via targeting RB1, up-regulating IL1RAP, and activating p38 MAPK pathway in vitro. Molecular & Cell Proteomics, 2017, pii: mcp.RA117.000432. (SCI, IF: 6.54).

　　Xiaoya Wang, Shanhua Wei, Yong Zhao, Changhong Shi, peijuan Liu, Caiqin Zhang, Yingfeng Lei, Bo Zhang, Bing Bai, Yong Huang*, Hai Zhang*. Anti-proliferation of breast cancer cells with itraconazole: Hedgehog pathway inhibition induces apoptosis and autophagic cell death. Cancer Lett. 2017, 385: 128-136; (SCI, IF: 6.375).

　　Dan Xu, Qian Du, Cong Han, Zengguo Wang, Xiujuan Zhang, Tongtong Wang, Xiaomin Zhao, Yong Huang*, Dewen Tong*. p53 signaling modulation of cell cycle arrest and viral replication in porcine circovirus type 2 infection cells. Veterinary Research. 2016 Nov 29;47(1):120. (SCI, IF: 2.928, 兽医学一区).

　　Delong Li, Qian Du, Bin Wu, Juejun Li, Lingling Chang, Xiaomin Zhao, Yong Huang*, Dewen Tong*, Immunogenicity of adenovirus vaccines expressing the PCV2 capsid protein in pigs. Vaccine, 2017. 35(36): 4722-4729. (SCI, IF: 3.235).

　　Na Xing, Xiaoxiao Guan, Bin An, Beibei Cui, Zengguo Wang, Xiaoya Wang, Xiujuan Zhang, Qian Du, Xiaomin Zhao, Yong Huang*, Dewen Tong* Ultrasensitive Detection of Porcine Epidemic Diarrhea Virus from Fecal Samples Using Functionalized Nanoparticles. Plos one. 2016, 11(12):e0167325.

　　Liang zhang, Zhenyu Wang, Jie Zhang, Xiaomao Luo, Qian Du, Lingling Chang, Xiaomin Zhao, Yong Huang*, Dewen Tong*. Porcine Parvovirus infection impairs progesterone production in Luteal Cells through MAPKs, p53 and mitochondria-mediated Apoptosis. Biol Reprod. 2018 Jan 18. doi: 10.1093/biolre/ioy014.

　　RuiChao Huo, LiLi Wang, XiaoYa Wang, Yong Zhao, Yi Wang, XiaoMin Zhao, LingLing Chang, SanLu Liu, DeWen Tong, Hai Zhang, Yong Huang*. Removal of Regulatory T cells prevents secondary chronic infection but increases the mortality of subsequent sub-acute infection in sepsis mice. Oncotarget. 2016, 7(10):10962-10975.

　　Hongling Zhang, Yong Huang, Lili Wang, Tingting Yu, Zengguo Wang, Lingling Chang, Xiaomin Zhao, Xiaomao Luo, Liang Zhang, Dewen Tong. Immortalization of porcine placental trophoblast cells through reconstitution of telomerase activity. Theriogenology. 2016;85(8):1446-56. (Co-First author)

　　Yong Huang，Na Xing，Zengguo Wang，Xiujuan Zhang，Xiaomin Zhao，Qian Du，Lingling Chang，Dewen Tong, Ultrasensitive Detection of RNA and DNA Viruses Simultaneously Using Duplex UNDP-PCR Assay，PLosOne, 2015,10(11): e0141545

　　Yong Huang, Feng Dong, Qian Du, Hongling Zhang, Xiaomao Luo, Xiangjun Song, Xiaomin Zhao, Wenlong Zhang, Dewen Tong. Swainsonine induces apoptosis through mitochondrial pathway and caspase activation in goat trophoblasts. Int J Biol Sci. 2014 Jul 11;10(7):789-97

　　Hongling Zhang, Yong Huang, Qian Du, Xiaomao Luo, Liang Zhang, Xiaomin Zhao,Dewen Tong, Porcine parvovirus infection induces apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated pathway . Biochem Biophys Res Commun, 2015. 456(2): 649-55. (Co-first authors).

　　Yong Huang, Xiujuan Zhang, Qian Du, Fengyu Wang, Xaiomin Zhao, Wenlong Zhang, Dewen Tong, Preclinical detection of porcine circovirus type 2 infection using an ultrasensitive nanoparticle DNA probe-based PCR assay, Plos one. 2014, 9(5): e97869.

　　Li Ding, Yong Huang, Qian Du, Feng Dong, Xiaomin Zhao, Wenlong Zhang, Xingang Xu, Dewen Tong. TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling. Biochem Biophys Res Commun. 2014, 445(2):497-503(Co-first authors).

　　Yong Huang, Li Ding, Zhaocai Li, Meiling Dai, Xiaomin Zhao, Wei Li, Qian Du, Xingang Xu, Dewen Tong. Transmissible gastroenteritis virus infection induces cell apoptosis via activation of p53 signalling. J Gen Virol. 2013, 94:1807-17.

　　Yong Huang, Meng Shao, Xingang Xu, Xiujuan Zhang, Qian Du, Xiaomin Zhao, Wenlong Zhang, Yahui Lyu, Dewen Tong. Evidence for different patterns of natural inter-genotype recombination between two PCV2 parental strains in the field. Virus Res. 2013,175(1):78-86.

　　Yong Huang, Wei Li, Xiaomin Zhao, Li Ding, Gaoshui Yu, Feng Dong, Qian Du, Xingang Xu, Dewen Tong. Swainsonine differentially affects steroidogenesis and viability in caprine luteal cells in vitro.Theriogenology. 2013 Jul 1;80(1):41-9.

　　Feng Dong, Yong Huang, Wei Li, Xiaomin Zhao, Wenlong Zhang, Qian Du, Hongling Zhang, Xiangjun Song, Dewen Tong. The isolation and characterization of a telomerase immortalized goat trophoblast cell line. Placenta, 2013,34(12): 1243–1250. (Co-first authors)

　　Li Ding, Yong Huang, Meiling Dai, Xiaomin Zhao, Qian Du, Feng Dong, LiliWang, Ruichao Huo, Wenlong Zhang, Xingang Xu, Dewen Tong. Transmissible gastroenteritis virus infection induces cell cycle arrest at S and G2/M phases via p53-dependent pathway. Virus Res. 2013，178(2):241-51 . (Co-first authors).

　　Yong Huang, YingFeng Lei, Hai Zhang, LiChao Hou, Mingjie Zhang, Andrew Dayton. MicroRNA regulation of STAT4 protein expression: rapid and sensitive modulation of interleukin-12 signaling in human natural killer cells. Blood. 2011,118(26):6793-802. (SCI, IF: 10.558)

　　Yong Huang, YingFeng Lei, Hai Zhang, Mingjie Zhang, Andrew Dayton. Interleukin-12 treatment down-regulates STAT4 and induces apoptosis with increasing ROS production in human natural killer cell. J Leukoc Biol. 2011, 90:87-97. (SCI, IF: 4.992)

　　五、科研项目

　　1. gC1qR在PCV2诱导巨噬细胞M2型极化过程中的作用与调控机制，国家自然科学基金面上项目，61万元，主持，2017-2020。

　　2. IL-12诱导的microRNAs对NK细胞功能及脓毒症形成的调控机制，国家自然科学基金，80万元，主持，2014-2017。

　　3. 西北农林科技大学“青年英才培育计划”青年卓越人才项目（2452017023）, 70万元，主持，2017-2019。

　　4. 利用UNDP-PCR技术早期检测猪腹泻主要病原PEDV和TGEV感染的研究与示范，陕西省农业科技创新与攻关，2015-2016。

　　5. 畜牧疫病防治关键技术研究，陕西省农业科技创新与攻关，2012-2013。

　　6. 脓毒症形成过程中NK细胞活性变化的分子调控机制研究，西北农林科技大学科技创新重点项目，2013-2015。

　　7. 猪重大疫病快速诊断新技术研究，西北农林科技大学国际科技合作基金项目， 2013-2015。

　　8. OMP25在布鲁氏菌免疫逃逸中的作用及其调控机制，西北农林大学引进人才科研启动项目， 2011-2014。

　　9. PCV2诱导猪巨噬细胞高表达IL-10的分子机制，基本科研业务费专项资金项目， 2015.7-2015.12。

　　六、联系方式

　　地址：陕西杨凌 365.com

　　邮编：712100

　　电子邮箱：huangyong@nwsuaf.edu.cn