华进联

作者:   来源:  发布日期:2016-04-19 浏览次数:

       一、个人基本信息

  华进联,男,博士,365.com/陕西省干细胞工程技术研究中心研究员(三级教授),博士生指导教师。

  兼任365.com基础兽医系副主任、动物生物技术学科点副点长;中国动物学会生殖生物学分会理事、中国动物学会细胞与分子显微技术学分会理事、中国生理学会生殖科学专业委员会理事、中国生物化学与分子生物学会农业生物化学与分子生物学会理事;《Cell Proliferation》、《Journal of Stem Cells and Clinical Practice》、《World Journal of Stem Cells ( WJSC)》等学术期刊编委。

  二、教育及研究经历

  教育经历:  1990.9-1995.7, 西北农业大学动物医学系,获农学学士学位; 1998.9-2001.7, 西北农业大学动物科技学院获临床兽医学专业硕士学位; 2001.9-2005.7, 西北农业大学动物科技学院获临床兽医学专业博士学位.

  研究工作经历:1995.7-2000.12,西北农林科技大学秦巴研究中心实习研究员;2001.1-2005.12, 西北农林科技大学动物科技学院助理研究员;2006.1-2010.12,365.com副研究员;2005.8-2006.8,澳大利亚新南威尔士大学医学院糖尿病移植中心博士后;2011.1至今, 365.com/陕西省干细胞工程技术研究中心研究员。

  三、研究方向及开设课程

  研究方向为动物干细胞与生殖细胞发育分化调控。在动物和人类胚胎干细胞、雄性生殖干细胞和iPS细胞及重要功能的成体干细胞发育分化调控等研究上取得了一系列有特色的研究进展。

  四、代表性学术成果(含论著、论文)

  申请国家发明专利10项,授权专利5项;发表论文120余篇, 其中SCI论文60余篇。主编或受邀参与出版著作6部。

  代表性学术论文和著作:

  [1] Na Li, Hailong Mu, Liming Zheng, Bo Li, Chongyang Wu, Bowen Niu, Qiaoyan      Shen, Xin He, Jinlian Hua *. (2016) EIF2S3Y suppresses the pluripotency state     and promotes the proliferation of mouse embryonic stem cells. Oncotarget,      2016 Feb 4. doi: 10.18632/oncotarget.7187. [Epub ahead of print]

  [2] Niu ZW, Zheng LM, Wu SY, Mu HL, Ma FL, Song WC, Zhu HJ, Wu J, He X, Hua JL *. 2015) Ras/ERK1/2 pathway regulates the self-renewal of dairy goat spermatogonia stem cells. Reproduction, 149, 445-452 DOI: 10.1530/rep-14-0506.

  [3]   Song, W.C., H.L. Mu, J. Wu, M.Z. Liao, H.J. Zhu, L.M. Zheng, X. He, B.W. Niu, Y.X. Zhai, C.L. Bai, A.M. Lei, G.P. Li*, J.L. Hua*. (2015) miR-544 Regulates Dairy Goat Male Germline Stem Cell Self-Renewal via Targeting PLZF. Journal of Cellular Biochemistry, 116, 2155-2165 DOI: 10.1002/jcb.25172.

  [4] Mu H, Li N, Wu J, Zheng L, Zhai Y, Li B, Song W, Wang J, Zhu H, Li G*, Hua J*. (2015) PLZF-Induced Upregulation of CXCR4 Promotes Dairy Goat Male Germline Stem Cell Proliferation by Targeting Mir146a. J Cell Biochem, Sep 14. doi: 10.1002/jcb.25371. [Epub ahead of print]

  [5]  Niu B, Wu J, Mu H, Li B, Wu C, He X, Bai C, Li G, Hua J*.(2015) miR-204 regulated the proliferation of dairy goat spermatogonial stem cells via targeting to Sirt1. Rejuvenation Res. Jul 27. [Epub ahead of print]

  [6] Zhu, H.J., J. Ma, R. Du, L.M. Zheng, J. Wu, W.C. Song, Z.W. Niu, X. He, E.Q. Du, S.T. Zhao, J.L. Hua*. (2014) Characterization of Immortalized Dairy Goat male Germline Stem Cells (mGSCs). Journal of Cellular Biochemistry. 115, 1549-1560 DOI: 10.1002/jcb.24812.

  [7] Wu, J., M.Z. Liao, H.J. Zhu, K. Kang, H.L. Mu, W.C. Song, Z.W. Niu, X. He, C.L. Bai, G.P. Li, X.P. Li*, J.L. Hua*. (2014) CD49f-Positive Testicular Cells in Saanen Dairy Goat Were Identified as Spermatogonia-Like Cells by miRNA Profiling Analysis. Journal of Cellular Biochemistry. 115, 1712-1723 DOI: 10.1002/jcb.24835.

  [8] Yu, M., H.L. Mu, Z.W. Niu, Z.L. Chu, H.J. Zhu, J.L. Hua*. (2014) miR-34c Enhances Mouse Spermatogonial Stem Cells Differentiation by Targeting Nanos2. Journal of Cellular Biochemistry. 115, 232-242 DOI: 10.1002/jcb.24655.

  [9] Tang F, Yao X, Zhu H, Mu H, Niu Z, Yu M, Yang C, Peng S, Li G*, Hua J*. (2014) Expression pattern of Ngn3 in dairy goat testis and its function in promoting meiosis by upregulating Stra8. Cell Prolif, 47(1):38-47. IF="3.28

  [10] Li M, Yu M, Liu C, Zhu H, He X, Peng S, Hua J*. (2013) miR-34c works downstream of p53 leading to dairy goat male germline stem-cell (mGSCs) apoptosis. Cell Prolif, 46(2):223-31.

  [11]  Wu J, Song W, Zhu H, Niu Z, Mu H, Lei A, Yang C, Peng S, Li X, Li G*, Hua J*. (2013) Enrichment and characterization of Thy1-positive male germline stem cells (mGSCs) from dairy goat (Capra hircus) testis using magnetic microbeads. Theriogenology, 80(9):1052-1060.

  [12] Hua J*, Zhu H, Pan Si, Liu C, Sun J, Ma X, Dong W, Liu W, Li W. (2011) Pluripotent male germline stem cells from goat fetal testis and their survival in mouse testis. Cellular Reprogramming, 13(2): 133-144.

  [13] Hua J*, Yu H, Liu S, Dou Z, Sun Y, Jing X, Yang C, Lei A, Wang H, Gao Z. Derivation, characterization of human embryonic germ cells: serum-free culture and potentiality of germ cell differentiation. Biomed Reprod Online, 2009, 19: 238-249.

  [14] Hua J*, Pan S, Yang C, Dong W, Dou Z, Sidhu KS. Derivation of male germ cell-like lineage from human bone marrow stem cells. Biomed Reprod Online, 2009, 19:99-105.

  [15] Hua J*, Yu H, Dong W, Yang C, Gao Z, Lei A, Sun Y, Pan S, Wu Y, Dou Z. Characterization of mesenchymal stem cells (MSCs) from human fetal lung:Potential differentiation of germ cells. Tissue and Cell, 2009 41:448-455.

  [16] Hua J, Sidhu KS*. Recent advances in the derivation of germ cells from the embryonic stem cells. Stem Cells and Development, 2008, 17:399-411.

  [17] 华进联主编. 干细胞研究与应用. 中国农业科学技术出版社: 2015年.

  五、科研项目

  主持承担国家和省部级等科研项目近20项,其中国家自然科学基金项目4项,国家转基因重大专项子课题1项,国家863子课题2项,教育部博士点基金1项、教育部重点科研项目1项、博士后基金及陕西省攻关等。

  六、荣誉及奖项

  教育部新世纪优秀人才(2009年),获陕西省科技一等奖2项,二等奖2项,厅局级一等奖4项。

  七、联系方式

  E-mail: jinlianhua@nwsuaf.edu.cn, jlhua2003@126.com

  电话:029-87080068  


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