童德文

　　一、基本情况

　　童德文，男，汉族，博士，三级教授，博士生导师，教育部新世纪优秀人才，陕西省三秦人才，陕西省重点科技创新团队“动物重大疫病新型疫苗研发创新团队”带头人，陕西省教学团队“基础兽医学教学团队”带头人，陕西省精品资源共享课程“ 动物病理解剖学”负责人，西北农林科技大学基础兽医学学科带头人。兼任中国畜牧兽医学会动物病理学分会常务理事、中国畜牧兽医学会动物毒物学分会常务理事、国家科技奖评审专家和国家自然科学基金评审专家等。

　　二、研究方向

　　动物病理、细胞生理及病理。

　　主要研究领域：

　　1.动物重大疫病病原与宿主细胞互作机制研究；

　　2.动物重大疫病新型疫苗研发。

　　三、个人简历

　　1994年7月研究生毕业获硕士学位并留校从事动物病理学教研工作。2001年1月获博士学位，同年12月晋升副教授，2002年遴选为硕士生导师。2005年被评为西北农林科技大学首批青年学术骨干，同年在新西兰Lincoln University研修。2007年遴选为博士生导师。近年来主要开展了猪传染性胃肠炎、猪细小病毒病和猪圆环病毒病的流行病学、病理机制、新型疫苗和早期诊断技术的研究，发表科研论文150余篇。作为发明人申请了10项发明专利，其中5项已经授权。主持国家自然科学基金、霍英东教育基金、国际科学基金、高等院校博士点基金、 陕西省科技统筹创新工程计划等项目，相关研究成果发表于Journal of Virology, Journal of Immunology, Journal of Biological Chemistry, Molecular & Cellular Proteomics, Frontiers in Immunology，Frontiers in Pharmacology, Veterinary Microbiology，Vaccine，Molecular and Cellular Endocrinology, Theriogenology，Journal of General Virology, Virus Research , Journal of Virological Methods等期刊，已培养毕业博士生13名、硕士生38名。

　　四、代表性论文

　　1.Tongtong Wang, Qian Du, Xingchen Wu, Yingying Niu, Lijuan Guan, Zhenyu Wang, Xiaomin Zhao, Shan-Lu Liu, Dewen Tong*, Yong Huang*, Porcine MKRN1 modulates the replication and pathogenesis of PCV2 by inducing capsid protein ubiquitination and degradation. Journal of Virology, 2018. 92(11): e00100-18.

　　2.Liang Zhang, Zhenyu Wang, Jie Zhang, Xiaomao Luo, Qian Du, Lingling Chang, Xiaomin Zhao, Yong Huang, Dewen Tong*, Porcine parvovirus infection impairs progesterone production in luteal cells through MAPKs, p53 and mitochondria-mediated apoptosis. Biology of Reproduction, 2018. doi: 10.1093/biolre/ioy014.

　　3.Xiaomin Zhao, Xiaoyuan Bai, Lijuan Guan, Juejun Li, Xiangjun Song, Xuelian Ma, Jianxiong Guo, Zhichao Zhang, Qian Du, Yong Huang*, Dewen Tong*, MicroRNA-4331 promotes transmissible gastroenteritis virus (TGEV)-induced mitochondrial damage via targeting RB1, upregulating interleukin-1 receptor accessory protein (IL1RAP), and activating p38 MAPK pathway in vitro. Molecular & Cellular Proteomics, 2018. 17(2): p. 190-204.

　　4.Beibei Cui, Wenli Liu, Xiaoya Wang, Yu Chen, Qian Du, Xiaomin Zhao, Hai Zhang, Shan-Lu Liu, Dewen Tong*, Yong Huang*, Brucella Omp25 upregulates miR-155, miR-21-5p, and miR-23b to inhibit interleukin-12 production via modulation of programmed death-1 signaling in human monocyte/macrophages. Frontiers in Immunology, 2017. 8(6): p. 1-15.

　　5.Xiaomao Luo, Xiujuan Zhang, Xingchen Wu, Xuefeng Yang, Cong Han, Zhenyu Wang, Xiaomin Zhao, Shan-Lu Liu, Dewen Tong*, Brucella down-regulates TNF-α to promote intracellular survival via Omp25 regulation of different microRNAs in porcine and murine macrophages. Frontiers in Immunology, 2018. 8(1): p. 1-17.

　　6.Zheng Lu, Lingling Chang, Qian Du, Yong Huang, Xiujuan Zhang, Xingchen Wu, Jie Zhang, Ruizhen Li, Zelin Zhang, Wenlong Zhang, Xiaomin Zhao, Dewen Tong*, Arctigenin induces an activation response in porcine alveolar macrophage through TLR6-NOX2-MAPKs signaling pathway. Frontiers in Pharmacology, 2018. doi: 10.3389/fphar.2018.00475.

　　7.Wenlong Zhang, Zelin Zhang, Jinxuan Chen, Dewen Tong*, Ghrelin is expressed in the pregnant mammary glands of dairy goats and promotes the cell proliferation of mammary epithelial cells. General and Comparative Endocrinology, 2018. 260(12): p. 115-124.

　　8.Wenlong Zhang, Zhenyu Wang, Liang Zhang, Zelin Zhang, Jinxuan Chen, Weicong Chen, Dewen Tong*, Melatonin stimulates the secretion of progesterone along with the expression of cholesterol side-chain cleavage enzyme (P450scc) and steroidogenic acute regulatory protein (StAR) in corpus luteum of pregnant sows. Theriogenology, 2018. 108(2): p. 297-305.

　　9.Liang Zhang, Yong Huang, Zhenyu Wang, Xiaomao Luo, Hongling Zhang, Qian Du, Lingling Chang, Xiaomin Zhao, Dewen Tong*, Establishment and characterization of a telomerase immortalized porcine luteal cells. Theriogenology, 2017. 94(11): p. 105-113.

　　10.Delong Li, Qian Du, Bin Wu, Juejun Li, Lingling Chang, Xiaomin Zhao, Yong Huang, Dewen Tong*, Immunogenicity of adenovirus vaccines expressing the PCV2 capsid protein in pigs. Vaccine, 2017. 35(36): p. 4722-4729.

　　11.Delong Li, Dan Xu, Zengguo Wang, Qian Du, Lingling Chang, Xiaomin Zhao, Yong Huang, Dewen Tong*, Immunogenicity evaluation of modified adenovirus vaccines expressing porcine circovirus type 2 capsid protein in pigs. Viral Immunol, 2017. 30(2): p. 111-119.

　　12.Dan Xu, Qian Du, Cong Han, Zengguo Wang, Xiujuan Zhang, Tongtong Wang, Xiaomin Zhao, Yong Huang, Dewen Tong*, p53 signaling modulation of cell cycle arrest and viral replication in porcine circovirus type 2 infection cells. Veterinary Research, 2016. 47(1): p. 120-131.

　　13.Hongling Zhang, Yong Huang, Lili Wang, Tingting Yu, Zengguo Wang, Lingling Chang, Xiaomin Zhao, Xiaomao Luo, Liang Zhang, Dewen Tong*, Immortalization of porcine placental trophoblast cells through reconstitution of telomerase activity. Theriogenology, 2016. 85(8): p. 1446-1456.

　　14.Delong Li, Yong Huang, Qian Du, Zhenyu Wang, Lingling Chang, Xiaomin Zhao, Dewen Tong*, CD40 Ligand and GMCSF coexpression enhance the immune responses and protective efficacy of PCV2 adenovirus vaccine. Viral Immunology, 2016. 29(3): p. 148-158.

　　15.Xiaomin Zhao, Hailing Xiang, Xiaoyuan Bai, Naijiao Fei, Yong Huang, Xiangjun Song, Hongling Zhang, Liang Zhang, Dewen Tong*, Porcine parvovirus infection activates mitochondria-mediated apoptotic signaling pathway by inducing ROS accumulation. Virology Journal, 2016. 13(1): p. 26-35.

　　16.Xiaomin Zhao, Xiangjun Song, Xiaoyuan Bai, Naijiao Fei, Yong Huang, Zhimin Zhao, Qian Du, Hongling Zhang, Liang Zhang, Dewen Tong*, miR-27b attenuates apoptosis induced by transmissible gastroenteritis virus (TGEV) infection via targeting runt-related transcription factor 1 (RUNX1). PeerJ, 2016. 4: p. 1635-1652.

　　17.Yunpeng Fan, Xia Ma, Jing Zhang, Lin Ma, Yuanyuan Gao, Weimin Zhang, Xiaoping Song*, Weifeng Hou, Chao Guo, Dewen Tong*, Ophiopogon polysaccharide liposome can enhance the non-specific and specific immune response in chickens. Carbohydrate Polymers, 2015. 119: p. 219-227.

　　18.Yunpeng Fan, Meimei Ren, Weifeng Hou, Chao Guo, Dewen Tong*, Lin Ma, Weimin Zhang, Mengmeng He, Xiaoping Song*, The activation of epimedium polysaccharide-propolis flavone liposome on Kupffer cells. Carbohydrate Polymers, 2015. 133: p. 613-623.

　　19.Xiangjun Song, Xiaomin Zhao, Yong Huang, Hailing Xiang, Wenlong Zhang, Dewen Tong*, Transmissible gastroenteritis virus (TGEV) infection alters the expression of cellular microRNA species that affect transcription of TGEV Gene 7. International Journal of Biological Sciences, 2015. 11(8): p. 913-922.

　　20.Xingang Xu, Honglei Zhang, Qi Zhang, Jie Dong, Yong Huang, Dewen Tong*, Porcine epidemic diarrhea virus M protein blocks cell cycle progression at S-phase and its subcellular localization in the porcine intestinal epithelial cells. Acta Virologica, 2015. 59(3): p. 265-275.

　　21.Hongling Zhang, Yong Huang, Qian Du, Xiaomao Luo, Liang Zhang, Xiaomin Zhao, Dewen Tong*, Porcine parvovirus infection induces apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated pathway. Biochemical and Biophysical Research Communications, 2015. 456(2): p. 649-655.

　　22.Li Ding, Yong Huang, Qian Du, Feng Dong, Xiaomin Zhao, Wenlong Zhang, Xingang Xu, Dewen Tong*, TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling. Biochemical and Biophysical Research Communications, 2014. 445(2): p. 497-503.

　　23.Yunpeng Fan, Xiaoping Song, Yuanyuan Gao, Ying Chen, Lin Ma, Weimin Zhang, Weifeng Hou, Chao Guo, Dewen Tong*, Preparation and optimization of ophiopogon polysaccharide liposome and its activity on Kupffer cells. International Journal of Pharmaceutics, 2014. 477(1-2): p. 421-430.

　　24.Yong Huang, Feng Dong, Qian Du, Hongling Zhang, Xiaomao Luo, Xiangjun Song, Xiaomin Zhao, Wenlong Zhang, Dewen Tong*, Swainsonine induces apoptosis through mitochondrial pathway and caspase activation in goat trophoblasts. International Journal of Biological Sciences, 2014. 10(7): p. 789-797.

　　25.Wei Li, Yong Huang, Xiaomin Zhao, Wenlong Zhang, Feng Dong, Qian Du, Dewen Tong*, Swainsonine induces caprine luteal cells apoptosis via mitochondrial-mediated caspase-dependent pathway. Journal of Biochemical and Molecular Toxicology, 2014. 28(10): p. 456-464.

　　26.Jun Zhang, Dan Xu, Jia Nie, Jingsong Cao, Yonggong Zhai, Dewen Tong*, Yuguang Shi*, Monoacylglycerol acyltransferase-2 is a tetrameric enzyme that selectively heterodimerizes with diacylglycerol acyltransferase-1. Journal of Biological Chemistry, 2014. 289(15): p. 10909-10918.

　　27.Li Ding, Yong Huang, Meiling Dai, Xiaomin Zhao, Qian Du, Feng Dong, Lili Wang, Ruichao Huo, Wenlong Zhang, Xingang Xu, Dewen Tong*, Transmissible gastroenteritis virus infection induces cell cycle arrest at S and G2/M phases via p53-dependent pathway. Virus Research, 2013. 178(2): p. 241-251.

　　28.Li Ding, Xiaomin Zhao, Yong Huang, Qian Du, Feng Dong, Hongling Zhang, Xiangjun Song, Wenlong Zhang, Dewen Tong*, Regulation of ROS in transmissible gastroenteritis virus-activated apoptotic signaling. Biochemical and Biophysical Research Communications, 2013. 442(1-2): p. 33-37.

　　29.Feng Dong, Yong Huang, Wei Li, Xiaomin Zhao, Wenlong Zhang, Qian Du, Hongling Zhang, Xiangjun Song, Dewen Tong*, The isolation and characterization of a telomerase immortalized goat trophoblast cell line. Placenta, 2013. 34(12): p. 1243-1250.

　　30.Yong Huang, Li Ding, Zhaocai Li, Meiling Dai, Xiaomin Zhao, Wei Li, Qian Du, Xingang Xu, Dewen Tong*, Transmissible gastroenteritis virus infection induces cell apoptosis via activation of p53 signaling. Journal of General Virology, 2013. 94: p. 1807-1817.

　　31.Yong Huang, Wei Li, Xiaomin Zhao, Li Ding, Gaoshui Yu, Feng Dong, Qian Du, Xingang Xu, Dewen Tong*, Swainsonine differentially affects steroidogenesis and viability in caprine luteal cells in vitro. Theriogenology, 2013. 80(1): p. 41-49.

　　32.Yong Huang, Meng Shao, Xingang Xu, Xiujuan Zhang, Qian Du, Xiaomin Zhao, Wenlong Zhang, Yahui Lyu, Dewen Tong*, Evidence for different patterns of natural inter-genotype recombination between two PCV2 parental strains in the field. Virus Research, 2013. 175(1): p. 78-86.

　　33.Xingang Xu, Honglei Zhang, Qi Zhang, Jie Dong, Yabing Liang, Yong Huang, Hungjen Liu*, Dewen Tong*, Porcine epidemic diarrhea virus E protein causes endoplasmic reticulum stress and up-regulates interleukin-8 expression. Virology Journal, 2013. 10: p. 26-33.

　　34.Xingang Xu, Honglei Zhang, Qi Zhang, Yong Huang, Jie Dong, Yabing Liang, Hungjen Liu*, Dewen Tong*, Porcine epidemic diarrhea virus N protein prolongs S-phase cell cycle, induces endoplasmic reticulum stress, and up-regulates interleukin-8 expression. Veterinary Microbiology, 2013. 164(3-4): p. 212-221.

　　35.Wenlong Zhang, Gaoshui Yu, Yong Huang, Dan Xu, Jingjing Ren, Liang Jiang, Changlong Wu, Dewen Tong*, Expression of ghrelin and GHSR-1a in mammary glands of dairy goat during the lactation and the effects of gherlin on regulation of mammary function in vitro . Molecular and Cellular Endocrinology, 2013. 370(1-2): p. 20-31.

　　36.Li Ding, Xingang Xu, Yong Huang, Zhaocai Li, Kuan Zhang, Guangda Chen, Gaoshui Yu,  Zhisheng Wang, Wei Li, Dewen Tong*, Transmissible gastroenteritis virus infection induces apoptosis through FasL- and mitochondria-mediated pathways. Veterinary Microbiology, 2012. 158(1-2): p. 12-22.

　　37.Wei Li, Xingang Xu, Yong Huang, Zhaocai Li, Gaoshui Yu, Zhisheng Wang, Li Ding, Dewen Tong*, Establishment and evaluation of a stable steroidogeniccaprine luteal cell line. Theriogenology, 2012. 78(2): p. 263-272.

　　38.Zhaocai Li, Yong Huang, Feng Dong, Wei Li, Li Ding, Gaoshui Yu, Dan Xu, Yuanyuan Yang, Xingang Xu, Dewen Tong*, Swainsonine promotes apoptosis in human oesophageal squamous cell carcinoma cells in vitro and in vivo through activation of mitochondrial pathway. Journal of Biosciences, 2012. 37(6): p. 1005-1016.

　　39.Xingang Xu, Guangda Chen, Yong Huang, Li Ding, Zhaocai Li, Chingdong Chang, Chiyoung Wang, Dewen Tong*, Hungjen Liu*, Development of multiplex PCR for simultaneous detection of six swine DNA and RNA viruses. Journal of Virological Methods, 2012. 183(1): p. 69-74.

　　40.Xingang Xu, Zhisheng Wang, Qi Zhang, Zhaocai Li, Li Ding, Wei Li, Hungyi Wu, Chingdong Chang, Longhuw Lee, Dewen Tong*, Hungjen Liu*, Baculovirus as a PRRSV and PCV2 bivalent vaccine vector: baculovirusvirions displaying simultaneously GP5 glycoprotein of PRRSV and capsid protein of PCV2. Journal of Virological Methods, 2012. 179(2): p. 359-366.

　　41.Xingang Xu, Kuan Zhang, Yong Huang, Li Ding, Guangda Chen, Honglei Zhang, Dewen Tong*, Bovine herpes virus type I induces apoptosis through Fas-dependent and mitochondria-controlled manner in Madin-Darby bovine kidney cells. Virology Journal, 2012. 9: p. 202-215.

　　42.Xingang Xu, Hongni Zhao, Qi Zhang, Li Ding, Zhaocai Li, Wei Li, Hungyi Wu, Kuopin Chuang, Dewen Tong*, Hungjen Liu*, Oral vaccination with attenuated salmonella entericaserovar typhimurium expressing Cap protein of PCV2 and its immunogenicity in mouse and swine models. Veterinary Microbiology, 2012. 157(3-4): p. 294-303.

　　43.Zhaocai Li, Xingang Xu, Yong Huang, Li Ding, Zhisheng Wang, Gaoshui Yu, Dan Xu, Wei Li, Dewen Tong*, Swainsonine activates mitochondria-mediated apoptotic pathway in human lung cancer A549 cells and retards the growth of lung cancer xenografts. International Journal of Biological Sciences, 2012. 8(3): p. 394-405.

　　44.Zhisheng Wang, Xingang Xu, Hungjen Liu, Zhaocai Li, Li Ding, Gaoshui Yu, Dewen Tong*, Immunogenicity of the envelope GP3 protein of porcine reproductive and respiratory syndrome virus displayed on baculovirus. Acta Virologica, 2011. 55(2): p. 139-146.

　　45.Zhisheng Wang, Xinggang Xu, Hungjen Liu, Zhaocai Li, Li Ding, Gaoshui Yu, Dan Xu, Dewen Tong*, Immunogenicity of envelope GP5 protein displayed on baculovirus and protective efficacy against virulent porcine reproductive and respiratory syndrome virus challenge in piglets. African Journal of Microbiology Research, 2011. 5(18): p. 2682-2691.

　　46.Xingang Xu, Dewen Tong, Zhisheng Wang, Qi Zhang, Zhaocai Li, Kuan Zhang, Wei Li, Hungjen Liu*, Baculovirus virions displaying infectious bursal disease virus VP2 protein protect chickens against infectious bursal disease virus infection. Avian Diseases, 2011. 55(2): p. 223-229.

　　47.Xingang Xu, Zhisheng Wang, Qi Zhang, Zhaocai Li, Hongni Zhao, Wei Li, Dewen Tong*, Hungjen Liu*, Baculovirus surface display of E envelope glycoprotein of Japanese encephalitis virus and its immunogenicity of the displayed proteins in mouse and swine models. Vaccine, 2011. 29(4): p. 636-643.

　　48.Jinyi Wang*, Li Ren, Li Li, Wenming Liu, Jing Zhou, Wenhao Yu, Dewen Tong, Shulin Chen, Microfluidics: a new cosset for neurobiology. Lab on a Chip, 2009. 9(5): p. 644-652.

　　49.Xingang Xu, Dewen Tong, Mingtang Chiou, Yaoching Hsieh, Wenling Shih, Chingdong Chang, Minghuei Liao, Yanming Zhang, Hungjen Liu*, Baculovirus surface display of NS3 nonstructural protein of classical swine fever virus. Journal of Virological Methods, 2009. 159(2): p. 259-264.

　　50.Xingang Xu, Mingtang Chiou, Yanming Zhang, Dewen Tong, Jianhe Hu, Miaotao Zhang, Hungjen Liu*, Baculovirus surface display of E-rns envelope glycoprotein of classical swine fever virus. Journal of Virological Methods, 2008. 153(2): p. 149-155.

　　51.Dewen Tong*, Jinyi Wang*, Peihong Mu, Qiang Dong, Baoyu Zhao, Wenming Liu, Jun Zhao, Li Li, Tao Zhou, Analysis of several serum enzymes and blood urea nitrogen of swainsonine-HSA immunized goats. Animal Feed Science and Technology, 2008. 142(1-2): p. 74-88.

　　五、科研项目

　　近年来主持的科研项目：

　　1. 国家自然科学基金

　　2. 霍英东教育基金

　　3. 国际科学基金

　　4. 高等院校博士点基金

　　5. 陕西省科技统筹创新工程计划项目

　　6. 中央重大农业技术推广资金项目

　　六、联系方式

　　电子邮箱：tdw8888@sina.com