张小莺

　　　一、个人简历

　　主要从事新药研发、抗体工程。2008年起任西北农林科技大学教授。先后毕业于中国药科大学药理学专业、德国柏林（洪堡、自由）大学Charite医学院硕士和博士(药理学)。先后在北京中国医药研究开发中心、德国卫生部罗伯特-科赫研究所等地从事新药与检测、诊断试剂研发工作。曾在世界卫生组织总部、比利时葛兰素制药公司、瑞典卡洛林斯卡大学、挪威Bergen大学、越南卫生部河内公共卫生学院、印度尼西亚GadjahMada大学等地短期工作、实习和学习。留德其间主要从事抗体工程及诊断、检测试剂开发研究。

　　曾主持和参与欧盟、德国卫生部、德国高校、德意志学术交流中心（DAAD）和国内自然基金委、教育部、科技部、农业部、留学基金委、外国专家局、陕西省等科研项目40余项，发表论文100余篇，其中SCI论文80余篇；专著2本，其中英文专著1本；主编教材3部；申请专利15项。培养的研究生中已有20余人次获得研究生国家奖学金/校长奖学金/德意志学术交流中心奖学金/校级优秀毕业论文。目前兼任国家留学基金评委、教育部留学人员科研启动基金、教育部博士点基金、欧盟PF7项目、霍英东青年教师基金及青年教师奖评审专家；农业部全国兽药残留与耐药性控制专家委员会委员；中国畜牧兽医学会兽医药理毒理学分会常务理事、兼任温州医科大学等高校客座教授；国务院外国专家局智力引进专家（2006-2008年）；国内外40多个刊物的副主编、编委或审稿人；德国病毒学会、国际药用植物与天然产物学会（GA）、德国遗传学会、留德生物医药学会、中国药理学会等学术团体会员、理事。南京、大连、山西等省、市政府顾问或特聘专家。被人民日报（海外版）、神州学人等多家媒体报道。

　　二、主要著作与论文

　　1.论文（2017-2014）：

　　（1）Xiaoying Zhang*, Calvert Rosaleen, Sutton Brian, Doré Katy*. IgY: A key molecule in antibody evolution. Biological reviews.2017. (SCI,一区, IF=11.615)

　　（2）Cui Li, Yaoyao Zhang, Sergei A. Eremin, Omar Yakup, Gang Yao, Xiaoying Zhang*. Detection of kanamycin and gentamicin residues in animal-derived food using IgY antibody based ic-ELISA and FPIA. Food Chemistry. 2017,227: 48-54. (SCI, 一区, IF="4.529)

　　（3）Abdul RasheedBaloch, Abdul Wahid Baloch, Brian J.Sutton, Xiaoying Zhang*. Antibody Mimetics: Promising complementary agents to animal-sourced antibodies. Critical Reviews in Biotechnology. 2016, 36(2): 268-275. (SCI, 一区, IF="6.542)

　　（4）Xuemei Jiang, Jianjun Hu, ThirumalaiDiraviyam, Xiaoying Zhang*. Immunoglobulin transporting receptors are potential targets for the immunity enhancement and generation of mammary gland bioreactor. Frontiers in Immunology. 2016, 7: 214. (SCI, 一区, IF="6.429)"

　　（5）Cui Li, Jinxin He, HaoRen, Enqi Du, Xiaoying Zhang*, Xinping Li. Preparation of a chicken scFv to analyze gentamicin residuein animal derived food products. Analytical chemistry, 2016, 88(7): 4092-4098. (SCI, 一区, IF="6.32）

　　（6）Zhihui Jiang, Xuemei Jiang, Cui Li, HuitingXue, Xiaoying Zhang*. Development of an IgY antibody-based immunoassay for the screening of the CYP2E1 inducer/inhibitor from herbal medicines. Frontiers in Pharmacology.2017. (SCI, 一区, IF= 4.400)

　　（7）Zhihui Jiang, JianWang,Huiting Xue, Meng Wang, Hai Jiang, Yinku Liang, Alberto C.Dias, Marslin Gregory, Chen Chen, Xiaoying Zhang*. Protective effect of wild Corni Fructus methanolic extract against acute alcoholic liver injury in mice. Redox Report.2016,7:1-8. (SCI, 四区, IF="2.070).

　 （8）　Meng Wang, Zhaoxiang Zhou, Jian Wang, Xiaoying Zhang*.An improved in vitro method for screening toxin and medicine target CYP2E1. Environmental Toxicology and Pharmacology. 2016,47:86-91. (SCI, 三区, IF="2.187).

　　（9）Zhihui Jiang, Jian Wang, Xinping Li, Xiaoying Zhang*.Echiancoside and Cistanchetubulosa (Schenk) R. Wight ameliorates bisphenol A-induced testicular and sperm damage in rats through gonad axis regulated steroidogenic enzymes. Journal of Ethnopharmacology. 2016, 193:321-328. (SCI,一区, IF="2.981).

　　（10）BinZhao, XiaoyingZhang *. Mathematical analysis of multi-antibiotic resistance.International Journal of Cardiology. 2016, 219:33-37.(SCI,一区, IF="6.189).

　　（11）WenyanXie, Meng Wang, Chen Chen, Xiaoying Zhang*, Matthias F Melzig. Hepatoprotective effect of isoquercitrin against acetaminophen-induced liver injury. Life Sciences. 2016, 152: 180-189. (SCI,二区, IF="2.936).

　　（12）Jinxin He, Yuan Wang, Xiaoying Zhang*. Preparation of arti?cial antigen and development of indirect competitive ELISA based on egg yolk-derived immunoglobulin (IgY) for the detection of Acid orange II in food samples. Food Analytical Methods. 2016, 9(2): 378-384. (SCI,二区, IF="2.038).

　　（13）Xiaoying Zhang*, ThirumalaiDiraviyama, Xiumei Li, Gang Yao & Antonysamy Michaeld. Preparation of chicken IgY against recombinant E2 protein of bovine viral diarrhea virus (BVDV) and Development of ELISA and ICA for BVDV detection. Bioscience, Biotechnology, and Biochemistry. 2016, 8(2):1-6.（SCI,三区, IF="1.295）

　　（14）Zhaoxiang Zhou, Meng Wang, Zengjun Guo, Xiaoying Zhang* Pharmacokinetic evaluation of the interaction between oral kaempferol and ethanol in rats. Acta Pharm. 2016,66:563-568. (SCI,四区, IF="1.288).

　　（15）TinaBuchholz, ChenChen, Xiaoying Zhang, M. F. Melzig*. Pancreatic lipaseand alpha-amylase inhibitory activities of plants used in Traditional Chinese Medicine.Pharmazie.2016,71(7):420-424. (SCI,三区, IF="1.264).

　　（16）TaoBai, ThirumalaiDiraviyam, Zhao Xiang Zhou, Zhihui Jiang, Xiaoying Zhang*.A novel method for correction of uterine torsion in Cows.Veterinarskiarhiv.2016, 86(6): 787-793. (SCI, 四区, IF="0.362).

　　（17）蒋志惠，谢文艳，李新平，张小莺*. 环境雌激素双酚A暴露现状及其雄性生殖毒性研究概况.生态毒理学报[J].2016, 11(4).

　　（18）江雪梅，张小莺*.pM蛋白对IgY的互作研究[J].中国科技论文在线精品论文,2017,,10(3): 341-345..

　　（19）江雪梅，张小莺*.免疫增强的潜在靶标--免疫球蛋白转运受体[J].中国科技论文在线精品论文,2016.

　　（20）米克热木?沙衣布扎提, 陈琛, 王萌, 王剑，张小莺*. 夏枯草水提物对吡唑-脂多糖诱导肝损伤的保护作用[J].食品安全质量检测学报. 2016, 7(6):2334-2338.

　　（21）WangJian, Chen Chen, JiangZhihui, WangMeng, Jiang Hai,Xiaoying Zhang*.Protective effect of cordycepsmilitarisextract against bisphenolainduced reproductivedamage.Systems Biology in Reproductive Medicine.2016, 62(4):249-57.(SCI, IF="1.176)

　　（22）Xuemei Jiang, Xiumei Li, Zhi Yang, Diraviyam T, Sergei A. Eremin, XiaoyingZhang*.Evaluation and optimization of three different immunoassays for rapid detection zearalenone in fodders. Food Analytical Methods. 2016,1-7.(SCI, 二区, IF="2.038).

　　（23）BinZhao, ThirumalaiDiraviyam,Xiaoying Zhang*.Biomathematical modeling on chronobiological rhythms of antibody- exemplified through Chicken IgY.  Biological Rhythm Research.2016, 47(6): 833-840.(SCI,四区, IF="0.695).

　　（24）HuitingXue, WenyanXie, Zhihui Jiang, Meng Wang, Jian Wang, Hongqiong Zhao, Xiaoying Zhang*. 3,4-dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, attenuates acetaminophen (APAP) induced liver injury through activation of Nrf-2.Xenobiotica. 2016, 46(10):931-939.(SCI, 四区, IF="1.932).

　　（25）ThirumalaiDiraviyam, Jinxin He, Chen Chen, Bin Zhao, Antonysamy Michael, and Xiaoying Zhang*.Effect of passive immunotherapy against Clostridium difficile infection (CDI): A Systematic Review and Meta-analysis.Immuno Therapy. 2016. 8(5):649-663. (SCI, 三区, IF="2.716).

　　（26）Meng Wang, Yuanguang Yu, Korbanjhon Brad, Wenyan Xie and Xiaoying Zhang*. The screening and evaluation of herbs and identification of herbal combinations with anti-viral effects on Newcastle disease virus. British poultry science. 2016, 57:34-43. (SCI, 二区, IF="0.933).

　  （27）HaoRen, Wenjing Yang, DiraviyamThirumalai, Xiaoying Zhang*,RüdigerSchade. A comparative evaluation of six principal IgY antibody extraction methods.Alternatives to laboratory animals. 2016,44(1):11-20. (SCI,三区, IF="1.021).

　　（28）Xuemei Jiang, ThirumalaiDiraviyam, Xiaoying Zhang*. Affinity purification of egg yolk immunoglobulins (IgY) using a human mycoplasma protein. Journal of Chromatography B.2016,1012-1013:37-41. (SCI,三区, IF="2.603).

　　（29）Xuemei Jiang, Yuan Wang, Xiaoying Zhang*. Data set for transcriptome analysis of the Chinese giant salamander (Andrias davidianus). Data in Brief. 2016,6:12-14.

　　（30）WenyanXie, Zhihui Jiang, Jian Wang, Xiaoying Zhang*, Matthias F. Melzig.Protective effect of hyperoside against acetaminophen (APAP) induced liver injury through enhancement of APAP clearance. Chemico-Biological Interactions. 2016,246:11-19. (SCI,二区, IF="3.143).

　　（31）ZhihuiJiang, Chen Chen, wenyanXie, MengWang, JianWang, XiaoyingZhang *. Anthocyanins attenuate alcohol-induced hepatic injury by inhibitingpro-inflammation signalling. Natural Product Research. 2016,30(4):469-473.(SCI, 四区, IF="1.828).

　　（32）Zhihui Jiang, Chen Chen, Jian Wang, Wenyan Xie, Meng Wang, Xinsheng Li*, Xiaoying Zhang*.Purple potato (Solanumtuberosum L.) attenuate alcohol-induced hepatic injury by enhancing antioxidant defense. Journal of Natural Medicines. 2016,70(1):45-53. (SCI,四区, IF="1.982).

　　（33）Hongxiu Chen, Fan He, Yuan Sun,Yuzi Luo, HuajiQiu*, Xiaoying Zhang*, , Brian J.Sutton. Generation and characterization of chicken-sourced single-chain variable fragments against porcine interferon-gamma. Journal of Immunoassay and Immunochemistry. 2015, 36(1): 27-44.

　　（34）Jinxin He, Jianjun Hu, Diraviyam Thirumalal, Ruediger Schade, Eenqi Du and Xiaoying Zhang*.Development of Indirect competitive ELISA using egg yolk-derived immunoglobulin (IgY) for the detection of Gentamicin residues. Journal Environment Science Health B. 2015,51(1):8-13.(SCI，四区, IF="1.247).

　　（35）王剑，王萌，周兆祥，陈琛，张小莺*.酸性橙II半抗原及人工抗原的合成与鉴定.食品安全质量检测学报[J]. 2015, 6(8): 3224-3229.

　　（36）Zhihui Jiang, Pervez Ahmed Khoso, Haidong Yao, Ziwei Zhang, Xiaoying Zhang*, ShiwenXu*. SelW regulates in?ammation-related cytokines in response to H2O2 in Se-de?cient chicken liver. RSC Advances. 2015, 5: 37896-37905. (SCI, 一区, IF="3.289)."

　　（37）库尔班江·巴拉提，王萌，张小莺*.苹果叶中总黄酮的提取及其含量测定[J].北方园艺. 2015, 14:129-132.

　　（38）JinxinHe, YuanWang, ShiqiSun, XiaoyingZhang *. Evaluation of Chicken IgY Generated Against Canine Parvovirus Viral-Like Particles and Development of Enzyme-Linked Immunosorbent Assay and Immunochromatographic Assay for Canine Parvovirus Detection.Viral immunology. 2015, 28(9):489-494. ( SCI,四区, IF="1513).

　　（39）Jinxin He, Yuan Wang, Xiaoying Zhang*. Preparation of artificial antigen and development of IgY based indirect competitive ELISA for the detection of kanamycin residues. Food Analytical Methods. 2015, 9(3): 744-751. (SCI,二区, IF="2.167)."

　　（40）张小莺*.兽用抗生素的合理使用与替代.中国畜牧业[J], 2015, 2: 45-46.

　　（41）YuanWang, XuemeiJiang, JinxinHe, ThirumalaiDiraviyam, XiaoyingZhang *.Quantitative investigation on correlation betweenIgG and FcRn during gestationand lactating periods in rat. American Journal of Reproductiv Immunology. 2016,75(2):81-85. (SCI, 三区, IF="3.202).

　　（42）WenyanXie, Chen Chen, Zhihui Jiang, Jian Wang, Matthias F. Melzig, Xiaoying Zhang*. Apocynumvenetum leaf extract attenuates acetaminophen overdose induced liver injury in mice. The American Journal of Chinese Medicine. 2015, 43(3): 457-476. (SCI，一区, IF="2.959)."

　　（43）Meng Wang, Jianguo Sun, Zhihui Jiang, WenyanXie, Xiaoying Zhang*. Hepatoprotectiveeffect of kaempferol against alcoholic liver injury in mice. The American Journal of Chinese Medicine. 2015, 43(2):241-254.(SCI, 一区, IF="2.959).

　　（44）张小莺*，王萌. 德国兽医教育及其对行业发展的影响. 2015, (5): 72-75.

　　（45）Xi Yao, HaoRen, Wenjing Yang, T. Diraviyam, Furong Tang, Meng Yu, JinlianHua, Xiaoying Zhang*, Sha Peng*. Expression of goat RNA binding protein (Nanos2), development and evaluation of anti-Nanos2 IgY antibodies. Czech Journal of Animal Science.2015, 60(4): 152-163.(SCI，三区, IF="0.809).

　　（46）李翠，张小莺*.鸡蛋的生物活性成分与综合利用[J].中国家禽.2015, 37(14): 62-64.

　　（47）Zehua Tian, Fei Shi, Fagang Zhong, Dingping Bai, Xiaoying Zhang*. Analysis of Fcgrt Gene Polymorphism in Indigenous Chinese Sheep and Its Association with Colostrum IgG Concentration. Genetics and Molecular Research. 2015,14(1): 2461-70. (SCI, 四区, IF="0.764).

　　（48）库尔班江·巴拉提，王萌，张小莺*. 大孔树脂富集分离葡萄叶总黄酮的研究[J]. 食品安全质量检测学报.2015,6(3):1-8.

　　（49）Tian Wang, Chen Chen, Man Yang, Baiwan Deng, Gordon Michael Kirby&ZhangXiaoying*. Anthocyanin attenuates alcohol-induced hepatic injury by inhibiting oxidative stress and pro-inflammation signaling. Natural levels by induction of testicular steroidgenic enzymes. 2016,54(3):481-487.(SCI,四区, IF="1.546).

　　（50）Bin Zhao, DiraviyamThirumalai, Xiaoying Zhang*. A bio-mathematical approach: Speculations to construct Virtual Placenta. Applied Mathematics and Computation. 2015, 256(4):344-351.(SCI, 一区, IF="1.345)."

　　（51）ChenChen, BalochAbdul Rasheed, JinxinHe, XiaoyingZhang*. A retrospective study on pet diseases and their medical interventions in Xi’an, China. Life Science Journal. 2014, 11(9): 971-975.(SCI, 三区, IF="2.687).

　　（52）刘晓强，李引乾，张小莺.氟喹诺酮类药物对陕西境内犬粪肠球菌的敏感性和防突变浓度[J]. 中国抗生素杂志. 2014, 39(2):151-154.

　　（53）王甜，王萌，蒋志惠，胡建军，孙建国，张小莺*.罗布麻茶黄酮提取物对小鼠CYP2E1的影响[J]. 食品安全质量检测学报.2014, 5(6). 1608-1614.

　　（54）XiaoshuangLiu, WenjingYang, JinxinHe, Jinzi. Zhao, Gutierrez C.E. Justo, Xiaoying Zhang*. Preparation of artificial antigen and egg yolk-derived immunoglobulin (IgY) of florfenicol amine for ELISA assay. Journal of Environmental Science and Health, Part B. 2014,49(2):109-115. (SCI，四区，IF=1.202).

　　（55）JinxinHe, DiraviyamThirumalai, RüdigerSchade, Xiaoying Zhang*, Chronobiological studies of chicken IgY: Monitoring of infradian, circadian and ultradian rhythms of IgY in blood and yolk of chickens. Veterinary Immunology and Immunopathology. 2014.160(3-4): 266-272. (SCI, 二区, IF="1.535).

　　（56）ThirumalaiDiraviyam, Bin Zhao, Yuan Wang, RuedigerSchade, Antonysamy Michael and Xiaoying Zhang*. Effect of chicken egg yolkantibodies (IgY) against diarrhea in domesticated animals: A Systematic Review and Meta-analysis. Plosone. 2014, 9(5), e97716. (SCI, 一区, IF="3.057).

　　（57）Yuan Wang, ZehuaTian, ThirumalaiDiraviyam, Xiaoying Zhang*.Neonatal Fc receptor (FcRn): A novel target for therapeutic antibodies and antibody engineering. Journalof Drug Targeting. 2014, 22(4): 269-278(SCI, 三区, IF="2.741)."

　　（58）ZehuaTian; Brian Sutton; Xiaoying Zhang*. Distribution of rat neonatal Fc receptor in the principal organs of neonatal and pubertal rats. Journal of Receptors and Signal Transduction.2014, 34(2): 137-142.(SCI,四区, IF="2.277).

　　（59）WenyanXie, Jianguo Sun, Xiaoying Zhang, M.F. Melzig*. Necrosis factor-alpha (TNF-α) response in human hepatoma HepG2 cells treated with hepatotoxic agents.Die Pharmazie - An International Journal of Pharmaceutical Sciences. 2014,69: 379–384.

　　（60）WenyanXie, XiaoyingZhang *, TianWang, S. Du. Pharmacokinetic analysis ofcefquinomeinhealthy chickens. British poultry science. 2013,54(1): 81-86.(SCI，三区，IF=1.147).

　　（61）田泽华，张小莺*.大鼠不同生理时期FcRn在脾脏和肾脏含量的动态分析[J].中国科技论文在线, 2013.

　　（62）WenyanXie, Chen Chen, Xiaoshuang Liu, Bo Wang, Maocang Yan, Xiaoying Zhang*. MeretrixMeretrix: Active Components and Their Bioactivities. Life ScienceJournal. 2012, 9(3):756-762. (SCI, 三区, IF="2.687).

　　（63）Tian Wang, Xiaoying Zhang*, WenyanXie. “Desert Ginseng”, Cistanchedeserticola Y. C. Ma, China. The American Journal of Chinese Medicine. 2012,40(6):1123-1141 (SCI, 二区, IF="2.959).

　　（64）ZehuaTian, Xiaoying Zhang*. Progress on research of chicken IgY antibody- FcRY receptor combination and transfer. Journal of Receptors and Signal Transduction. 2012:32(5): 231-237(SCI, 四区, IF="1.782).

　　（65）Shuizhong Han, Xiaoying Zhang*,Jinzi Zhao. Production of Egg Yolk Antibody (IgY) against Recombinant Canine Parvovirus VP2 Protein. Acta Scientiae Veterinariae. 2012: 40(2):1029. (SCI, 四区, IF="0.198)."

　　（66）WenyanXie, Xiaoying Zhang*, Tian Wang, Jianjun Hu. Apocynumvenetum L. (Luobuma) – A review on botany, traditional Uses, phytochemistry and pharmacology, China. Journal of Ethnopharmacology. 2012,141(1):1-8. (SCI, 二区, IF="3.055)."

　　（67）FagangZhong, Na Li, Xin Huang, Yan Guo, Xinhua Wang, Changqing Shi, Xiaoying Zhang*.Genetic typing and epidemiologic observation of bovine viral diarrhea virus in Xinjiang, China. Virus Genes. 2011, 42(2):204-207.(SCI, 四区, IF="1.837).

　　（68）Xiaoying Zhang*, Hongxiu Chen, ZehuaTian，Shulin Chen and RuedigerSchade. Chicken monoclonal IgY antibody: A novel antibody development strategy. Avian biology research. 2010.3(3):97-106. (SCI, 四区, IF="0.808).

　　2.专著

　　- Bioactive Egg Compounds. Springer-Verlag Berlin Heidelberg出版社, 德国. ISBN-13：978-3-540-37883-9, 2007.

　　- 卵黄抗体技术. 科学出版社. ISBN-978-7-03-030902-0, 2011.05.

　　3. 主编教材

　　食品安全学.主编.科学出版社. 2012.08第一版；2017年第二版

　　普通高等教育“十二五”规划教材;中国科学院系列教材. ISBN 978-7-03-034526-5.

　　功能性食品学.主编.科学出版社.2012.08；2017年第二版

　　普通高等教育“十二五”规划教材;中国科学院系列教材. ISBN 978-7-03-034529-5/TS.235.

　　兽医药剂学实验指导.主编.中国农业出版社. ISBN 978-7-109-17194-72012，国家级动物科学实验教学示范中心系列资助教材.

　　4.译著

　　默克兽医手册（第十版）.译者. 中国农业出版社2015年.“十二五”国家重点图书.

　　主审. 小动物药物手册（第七版）(2014-BSAVA Small Animal Formulary 7th)；中国农业出版社；ISBN 978-7-109-17863-2；“十二五”国家重点图书出版规划项目“世界兽医经典著作译丛”；2014.05. （Ian Ramsey主编；袁占奎裴增阳主译；张小莺主审；BSAVA：英国小动物医师协会）

　　5.发明专利：15项

　　三、联系方式：

　　电话兼传真：029-87091239(办公室)

　　电子邮件：zhang.xy@nwsuaf.edu.cn

　　办公地址：365.com4331

　　实验室地址：365.com4319

　　通讯地址：712100陕西杨凌示范区西农路22号365.com19号信箱